AgreenSkills session, year: 2nd session, 2016
Receiving laboratory: Douglas Mental Health University Institute, The hippocampal rythm lab, Canada
Country of origin : France
Effect of n-3 PUFA deficiency on neuronal assemblies of the reward system
Limited efficacy and adverse side-effects of conventional medications for psychiatric disorders highlight an urgent need to identify modifiable risk and resilience mechanisms to find novel treatment strategies. In this context, substantial evidence has suggested an implication of n-3 polyunsaturated fatty acids (PUFA) deficiency in the pathophysiology of different recurrent psychiatric disorders, including major depression, bipolar disorder and schizophrenia. However, these findings are only correlative, and the beneficial effects of n-3 PUFA nutritional supplementation on symptoms are still controversial. Therefore, there is a real need to conduct thorough preclinical studies in order to 1) identify the mechanisms by which n-3 PUFA deficiency can participate to the etiology of psychiatric endophenotypes and 2) determine how n-3 PUFA nutritional supplementation can exert beneficial effects on psychiatric symptoms and treatment efficacy. We obtained strong evidence that n-3 PUFA deficiency in mice leads to neurobiological and behavioral alterations that resemble some endophenotypes of the psychiatric disorders cited above. Deficient animals display impairments in reward processing accompanied by alterations in network activity of the nucleus accumbens (NAc), a central structure for reward. The goal of this project is therefore to determine the functional changes of NAc networks induced by n-3 PUFA deficiency using calcium imaging in behaving animals. This study will bring important information for the design of nutritional approaches for the prevention of some psychiatric symptoms.
My research interests focus on understanding the mechanisms behind alterations of reward processing in psychiatric disorders. Over the last 4 years, my main focus concerned the implication of alterations in lipid metabolism in some endophenotypes of psychiatric diseases. I obtained my PhD in 2006 at the university of Bordeaux under the supervision of Jacques Micheau. I then moved to New York City for postdoctoral training at Columbia University in Eric Kandel lab. In 2010 I became research associate at the Research Foundation for mental Hygiene at Columbia University and collaborated with the lab of Jonathan Javitch. In 2013 I obtained a faculty position at INRA and moved to the NutriNeuro Institute in Bordeaux. There I started a new project aiming at unraveling the impact of n-3 PUFA deficiency on the development and functionality of the reward system using a multidisciplinary approach, from biophysics to behavior.
1- Trifilieff P., Ducrocq F, van der Veldt S and Martinez D. Blunted dopamine transmission in addiction: potential mechanisms and implications for behavior. Seminars in Nuclear Medicine, 2017. PMID: 27987559;
2- Tantot F., Parkes SL., Marchand AR., Boitard C., Naneix F., Laye S., Trifilieff P., Coutureau E. and Ferreira G. The effect of high-fat diet consumption on appetitive instrumental behavior in rats. Appetite, 2016. PMID: 27713085;
3- Frederick AL.*, Yano H.*, Trifilieff P.*, Vishwasrao HD., Biezonski D., Meszaros J., Sibely DR., Kellendonk K., Sonntag K., Graham DL, Colbran RJ., Stanwood GD. and Javitch JA. Evidence against dopamine D1/D2 receptor heteromers. Molecular Psychiatry, 2015. *equally contributed. PMID: 25560761.
• Cited in Faculty of 1000;
4- Cahill E. *, Pascoli V. *, Trifilieff P., Savoldi D., Kappès V., Lüscher C., Caboche J. and Vanhoutte P. D1R/GluN1 complexes in the striatum integrate dopamine and glutamate signalling to control synaptic plasticity and cocaine-induced responses. Molecular Psychiatry, 2014. *equally contributed. PMID: 25070539;
• Cover article
5- Trifilieff P. and Martinez D. Imaging addiction: D2 receptors and dopamine signaling in the striatum as biomarkers for impulsivity. Neuropharmacology, 2013. PMID: 23851257;
6- Trifilieff, P, Feng B, Urizar E , Winiger V, Ward RD, Taylor KM, Martinez D, Moore H, Balsam PD, Simpson EH, and Javitch JA. Increasing dopamine D2 receptor expression in the nucleus accumbens enhances motivation. Molecular Psychiatry, 2013. PMID: 23711983.
• Cited in Faculty 1000. Cover article. Highlighted article.
2014 Idex Bordeaux “Chaire d’installation Junior”
2013 NARSAD (Brain and Behavior Research Foundation) Young Investigator Award
2010 Research Associate award from the ”Research Foundation for Mental Hygiene”, Columbia University
2007 Postdoctoral Fellowship from the “Fondation pour la Recherche Medicale”
2005 Doctoral award from the “Fondation pour la Recherche Medicale” (declined)
2005 Doctoral Fellowship from the “Fondation Jerome Lejeune”