Marina Romani Perez
AgreenSkills session, year: 1st session, 2014
Receiving laboratory: NutriNeuro Nutrition and integrated neurobiology Bordeaux Aquitaine, France
Country of origin : Spain
Influence of early chronic stress and early exposure to highly palatable food on food-motivated behavior and reward neural pathways
Obesity, which involves other obesity-induced complications such as type 2 diabetes, cardiovascular diseases and psychological and psychiatric health problems, has become the new epidemic of the XXI century. All of these disorders show a worrying increase over the years therefore all the efforts are being focused on prevention as early as possible in life. Gestation and lactation are critical periods when life experiences have a strong impact on offspring. A compulsive eating behavior leads to obesity due to the great availability of highly palatable food in westernized societies. Therefore, the exposure to external factors capable of modifying the neural circuits regulating eating behavior is a potential risk factor to induce obesity. In fact, it has been reported that early-life exposure to palatable food increases the risk to obesity later in life and modifies the eating behavior. Additionally, maternal behavior plays a key role in the development of brain and normal endocrine axis function in offspring. Particularly, chronic maternal deprivation produces a permanent alteration of the hypothalamic-pituitary-adrenal (HPA)-axis which has been linked to anxiety-like behavior. However, to date, potential mechanisms responsible for a perinatal programming of food preference and food motivated behavior that then lead to obesity are not well understood. The purpose of this project is to investigate the mechanisms involved in the impact of early life exposure to palatable food and chronic stress on the neural circuits involved in eating behavior.
My current research interest is the study of the mechanisms involved in fetal programming of adult diseases focusing on metabolic and food-motivated behavioral disturbances.
I obtained my undergraduate degree in Molecular Biology in the University of Santiago de Compostela (Spain). I was awarded a scholarship to develop my PhD in Endocrinology under the supervision of Professor Federico Mallo, in the University of Vigo (Spain). My PhD was focused on the long-term consequences of prematurity and early-life nutrition on cardiopulmonary diseases development as well as the effects of diabetes and obesity in adulthood on cardiopulmonary function emphasizing in the putative clinical role of glucagon like peptide-1 analogues.
Gil-Lozano M, Romaní-Pérez M, Outeiriño-Iglesias V, Vigo E, Brubaker PL, González-Matías LC, Mallo F. Corticotropin-releasing hormone and the adrenal medulla are major mediators in the effects of peripherally administered exendin-4 on the hypothalamic-pituitary-adrenal axis of male rats. Endocrinology. 2014;155(7):2511-23.
Gil-Lozano M, Romaní-Pérez M, Outeiriño-Iglesias V, Vigo E, Brubaker PL, González-Matías LC, Mallo F. Effects of prolonged exendin-4 administration on hypothalamic-pituitary-adrenal axis activity and water balance. Am J Physiol Endocrinol Metab. 2013; 304(10): 1105-1117.
Romaní-Pérez M, Outeiriño-Iglesias V, Gil-Lozano M, González-Matías LC, Mallo F, Vigo E. Pulmonary GLP-1 receptor increases at birth and exogenous GLP-1 receptor agonists augmented surfactant- protein levels in litters from normal and nitrofen-treated pregnant rats. Endocrinology. 2013;154(3): 1144-1155.
Second prize for best oral communications exposed in basic endocrinology at the 54 Congress of the Spanish Society of Endocrinology and Nutrition (SEEN), Oviedo 2012.
Second prize for best oral communications exposed in basic endocrinology at the 55 Congress of the Spanish Society of Endocrinology and Nutrition (SEEN), Granada
First prize for the best basic research communication of the XXV Congress of Galician Society of Endocrinology, Nutrition and Metabolism
(SGENM). Santiago de Compostela 2012.