Maria Razzauti Sanfelui

Maria Razzauti Sanfelui
country

AgreenSkills session, year: 2nd session, 2012

Receiving laboratory: CBGP Centre for Biology and Management of Populations Montpellier, France

Country of origin : Finland

E-Mail: Maria.razzauti@supagro.inra.fr

 

 

Mobility project

Characterization of novel rodent- and tick-borne viruses: prevalence, distribution, molecular variation and interaction with other microorganisms in rodents and ticks

Characterization of novel rodent- and tick-borne viruses: prevalence, distribution, molecular variation and interaction with other microorganisms in rodents and ticks

Rodents and ticks and are reservoirs and/or vectors of many human and livestock diseases. Some zoonotic pathogens are difficult to detect because they are unknown or poorly characterized. Furthermore, there is clear evidence of co-infections by several microorganisms (pathogens, symbionts and commensals) in rodents and ticks. However, the effect of these co-infections on pathogen transmission is yet unknown. Therefore efforts are needed to develop efficient methods to identify unknown pathogens in order to provide tools for appropriate diagnostics. In this context, the National Institute for Agronomical Research (INRA) is funding the project PATHO-ID.

The PATHO-ID project aims to establish a catalogue of microorganisms, including new or unexpected pathogens, symbionts and commensals present in rodents and ticks; to identify their distribution among natural populations; and to enlighten possible interactions between such microorganisms. In this frame, the VIRUS-ID subproject aims to study viruses identified by the PATHO-ID consortium. In particular, VIRUS-ID will assess (1) the prevalence and distribution of circulating viruses in rodents and ticks populations; (2) their molecular variation related to their presence in rodents and/or ticks; and (3) their co-occurrence (and possible interactions or associations, either positive or negative) with other microorganisms that could interfere with their transmission.

Biography & research interests

The research interest of Maria Razzauti is emerging zoonotic pathogens. She was born in Barcelona and obtained a MSc degree in Biology at the University of the Balearic Islands, Spain. Maria conducted her PhD in Virology by at the Faculty of Medicine of the University of Helsinki (Haartman Institute) and at the Finnish Forest Research Institute (Metla), Finland. Thereafter, she joined the Centre for Biology and Management of Populations (CBGP; a joint research unit of INRA, CIRAD, IRD and Supagro-Montpellier) in Montpellier to conduct research on host-parasites coevolution. In 2012, Maria was granted with an AgreenSkills fellowship to perform the VIRUS-ID project, which aimed to characterize rodent- and tick-borne pathogens, viruses in particular. Nowadays, she holds a postdoctoral research position at CBGP; her main task is to develop a new multiplexing technique that detects a large spectrum of viruses without any consciousness of their presence in multiple hosts simultaneously analysed. Her research interest focus on ecology and evolution of zoonotic infectious pathogens, especially vector-borne emerging pathogens; molecular evolution of etiologic microorganisms; the emergence of novel pathogens; within-host dynamics and between-host transmission; host immune-resistance to parasites; and intra-host interactions of different pathogens.

Selected publications

Maria Razzauti, Angelina Plyusnina, Heikki Henttonen, Alexander Plyusnin. Microevolution of Puumala hantavirus during a complete population cycle of its host, the bank vole (Myodes glareolus). PLoS One 2013, 8(5):e64447.

Angelina Plyusnina*, Maria Razzauti*, Tarja Sironen, Jukka Niemimaa, Heikki Henttonen, Alexander Plyusnin. Analysis of complete Puumala hantavirus genomes recovered from a fatal case of nephropathia epidemica and bank voles (Myodes glareolus) from the site of infection. Emerging Infectious Diseases 2012, 18(12):2070-2.

Maria Razzauti, Angelina Plyusnina, Jukka Niemimaa, Heikki Henttonen, Alexander Plyusnin. Co-circulation of two Puumala hantavirus lineages in Latvia: A Russian lineage described and a novel Latvian lineage. Journal of Medical Virology 2012, 84:314-318.

Maria Razzauti, Angelina Plyusnina, Tarja Sironen, Heikki Henttonen, Alexander Plyusnin. Analysis of Puumala hantavirus in a bank vole population in Fennoscandia: Evidence for co-circulation of two genetic lineages and frequent reassortment between wild-type strains. Journal of General Virology 2009, 90:1923-1931.

Maria Razzauti, Angelina Plyusnina, Heikki Henttonen, Alexander Plyusnin. Accumulation of point mutations and reassortment of genomic RNA segments are involved in the microevolution of Puumala hantavirus in a bank vole (Myodes glareolus) population. Journal of General Virology 2008, 89:1649-1660.

*Equal contribution

Contact:

E-Mail: Maria.razzauti@supagro.inra.fr

Website(s): http://www1.montpellier.inra.fr/cbgp/?q=fr/content/razzauti-sanfeliu-maria

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