AgreenSkills session, year: 2nd session, 2016
Receiving laboratory: IRSD, Toulouse
Country of origin : Canada
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Unravelling the role of epithelial and microbial proteases on microbiota biofilm dysbiosis associated with alimentary infection caused by pathogenic Escherichia coli
The relocation to France is the second major move on my ‘personal path’ to building a career in biomedical science. I am confident that my drive and ambition to achieve the intellectual and practical goals set out in this project will ensure that this AgreenSkills+ Fellowship will be a crucial period in my progress to professional maturity. I am truly confident that chosen host organisation (IRSD, Toulouse) will provide me all the support and aid I could wish for the satisfactory completion of this project. At the completion of this AgreenSkills+ fellowship, I am confident that I will have reached sufficient professional maturity to be able to apply my skills to important research goals in having scientific and social impact. In doing so, I believe I will have truly matured as a European Scientist, able to address through my research some major health issues of the European Community.
I always aspire to become an independent researcher in a national research institutes in France. I am keen to train the future generation of thinkers and to instill in them, a sense of passion for fundamental research in biomedical field. My education and research training to date, has chalked out this clear trajectory for me. This AgreenSkills+ fellowship will help me to achieve this professional goal, by financing my return in France at the Research Institute on Digestive Health (IRSD, Toulouse, INSERM U1220) after 31/2 years of postdoctoral training at the University of Calgary (Alberta, Canada). This support will help me to continue to build on my previous professional experiences and to expand my personal circle of partnerships and collaborations. My research has always been motivated by its potential translational impact, and thus my current project is designed to lead to the discovery of mechanisms and mediators for the treatment of intestinal infection and chronic inflammation. My decision to complete my postdoctoral training at the IRSD – coupled with an AgreenSkills+ fellowship – is thus both strategic and beneficial, as it will help me to achieve my career goals while creating and disseminating new knowledge which will have bench to market to bed expectations.
PUBLICATIONS LIST, ∆ most relevant publications
• C. Rolland-Fourcade, A. Denadai-Souza, C. Cirillo, C. Lopez, J. O. Jaramillo, C. Desormeaux, N. Cenac, J. P. Motta, M. Larauche, Y. Tache, P. V. Berghe, M. Neunlist, E. Coron, S. Kirzin, G. Portier, D. Bonnet, L. Alric, S. Vanner, C. Deraison, N. Vergnolle, Epithelial expression and function of trypsin-3 in irritable bowel syndrome. Gut, (2017).
• J. K. Beatty, S. V. Akierman, J. P. Motta, S. Muise, M. L. Workentine, J. J. Harrison, A. Bhargava, P. L. Beck, K. P. Rioux, G. W. McKnight, J. L. Wallace, A. G. Buret, Giardia duodenalis induces pathogenic dysbiosis of human intestinal microbiota biofilms. Int J Parasitol, (2017).
• T. Allain, C. B. Amat, J.-P. Motta, A. Manko, A. G. Buret, Interactions of Giardia sp. with the intestinal barrier: Epithelium, mucus, and microbiota. Tissue Barriers 5, e1274354 (2017).
• Halliez, M.C., J.P. Motta, T.D. Feener, G. Guerin, L. LeGoff, A. Francois, E. Colasse, L. Favennec, G. Gargala, T.K. Lapointe, C. Altier and A.G. Buret (2016). “Giardia duodenalis induces para-cellular bacterial translocation and causes post-infectious visceral hypersensitivity.” Am J Physiol Gastrointest Liver Physiol: ajpgi 00144 02015.
• ∆ Motta, JP., K. L. Flannigan, T. A. Agbor, J. K. Beatty, R. W. Blackler, M. L. Workentine, G. J. Da Silva, R. Wang, A. G. Buret and J. L. Wallace (2015). “Hydrogen Sulfide Protects from Colitis and Restores Intestinal Microbiota Biofilm and Mucus Production.” Inflammatory Bowel Diseases 21(5): 1006-1017.
• Buret, A., C. Amat, A. Manko, J. Beatty, M. M. Halliez, A. Bhargava, J.-P. Motta and J. Cotton (2015). “Giardia duodenalis: New Research Developments in Pathophysiology, Pathogenesis, and Virulence Factors.” Current Tropical Medicine Reports 2(3): 110-118.
• Wallace, J. L., R. W. Blackler, M. V. Chan, G. J. Da Silva, W. Elsheikh, K. L. Flannigan, I. Gamaniek, A. Manko, L. Wang, JP. Motta and A. G. Buret (2015). “Anti-Inflammatory and Cytoprotective Actions of Hydrogen Sulfide: Translation to Therapeutics.” Antioxidants & Redox Signaling 22(5): 398-410.
• ∆ Bermudez-Humaran, L. G.*, JP. Motta*, C. Aubry, P. Kharrat, L. Rous-Martin, J. M. Sallenave, C. Deraison, N. Vergnolle and P. Langella (2015). “Serine protease inhibitors protect better than IL-10 and TGF-beta anti-inflammatory cytokines against mouse colitis when delivered by recombinant lactococci.” Microbial Cell Factories 14(26). doi:10.1186/s12934-015-0198-4
• Flannigan, K. L., T. A. Agbor, JP. Motta, J. G. P. Ferraz, R. Wang, A. G. Buret and J. L. Wallace (2015). “Proresolution effects of hydrogen sulfide during colitis are mediated through hypoxia-inducible factor-1 alpha.” Faseb Journal 29(4): 1591-1602.
• Blackler, R. W., JP. Motta, A. Manko, M. Workentine, P. Bercik, M. G. Surette and J. L. Wallace (2015). “Hydrogen sulphide protects against NSAID-enteropathy through modulation of bile and the microbiota.” British Journal of Pharmacology 172(4): 992-1004.
• Cotton, J. A., JP. Motta, L. P. Schenck, S. A. Hirota, P. L. Beck and A. G. Buret (2014). “Giardia duodenalis Infection Reduces Granulocyte Infiltration in an In Vivo Model of Bacterial Toxin-Induced Colitis and Attenuates Inflammation in Human Intestinal Tissue.” Plos One 9(10).
• ∆ Galipeau, H. J.*, M. Wiepjes*, JP. Motta, J. D. Schulz, J. Jury, J. M. Natividad, I. Pinto-Sanchez, D. Sinclair, P. Rousset, R. Martin-Rosique, L. Bermudez-Humaran, J. C. Leroux, J. A. Murray, E. Smecuol, J. C. Bai, N. Vergnolle, P. Langella and E. F. Verdu (2014). “Novel Role of the Serine Protease Inhibitor Elafin in Gluten-Related Disorders.” American Journal of Gastroenterology 109(5): 748-756.
• Natividad, J. M. M.*, C. L. Hayes*, JP. Motta, J. Jury, H. J. Galipeau, V. Philip, C. L. Garcia-Rodenas, H. Kiyama, P. Bercik and E. F. Verdu (2013). “Differential Induction of Antimicrobial REGIII by the Intestinal Microbiota and Bifidobacterium breve NCC2950.” Applied and Environmental Microbiology 79(24): 7745-7754.
• Le Faouder, P., V. Baillif, I. Spreadbury, JP. Motta, P. Rousset, G. Chene, C. Guigne, F. Terce, S. Vanner, N. Vergnolle, J. Bertrand-Michel, M. Dubourdeau and N. Cenac (2013). “LC-MS/MS method for rapid and concomitant quantification of pro-inflammatory and pro-resolving polyunsaturated fatty acid metabolites.” Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences 932: 123-133.
• LG. Bermudez-Humaran, C. Aubry, JP. Motta, C. Deraison, L. Steidler, N. Vergnolle, JM. Chatel. & P. Langella. Engineering lactococci and lactobacilli for human health. Current opinion in microbiology, doi:10.1016/j.mib.2013.06.002 (2013).
• Gobbetti, T., N. Cenac, JP. Motta, C. Rolland, L. Martin, P. Andrade-Gordon, M. Steinhoff, E. Barocelli and N. Vergnolle (2012). “Serine Protease Inhibition Reduces Post-Ischemic Granulocyte Recruitment in Mouse Intestine.” American Journal of Pathology 180(1): 141-152.
• ∆ Motta, JP.*, L. G. Bermudez-Humaran*, C. Deraison, L. Martin, C. Rolland, P. Rousset, J. Boue, G. Dietrich, K. Chapman, P. Kharrat, JP. Vinel, L. Alric, E. Mas, J. M. Sallenave, P. Langella and N. Vergnolle (2012). “Food-Grade Bacteria Expressing Elafin Protect Against Inflammation and Restore Colon Homeostasis.” Science Translational Medicine 4(158).
• ∆ Motta, JP.*, L. Magne*, D. Descamps, C. Rolland, C. Squarzoni-Dale, P. Rousset, L. Martin, N. Cenac, V. Balloy, M. Huerre, L. F. Frohlich, D. Jenne, J. Wartelle, A. Belaaouaj, E. Mas, JP. Vinel, L. Alric, M. Chignard, N. Vergnolle and J. M. Sallenave (2011). “Modifying the Protease, Antiprotease Pattern by Elafin Overexpression Protects Mice From Colitis.” Gastroenterology 140(4): 1272-1282.
• Cenac, N., C. Altier, JP. Motta, E. d’Aldebert, S. Galeano, G. W. Zamponi and N. Vergnolle (2010). “Potentiation of TRPV4 signalling by histamine and serotonin: an important mechanism for visceral hypersensitivity.” Gut 59(4): 481-488.
• Djouani-Tahri, E. B., JP. Motta, F.-Y. Bouget and F. Corellou (2010). “Insights into the regulation of the core clock component TOC1 in the green picoeukaryote Ostreococcus.” Plant signaling & behavior 5(3): 332-335.
• Corellou, F., C. Schwartz, JP. Motta, E. Djouani-Tahri, F. Sanchez and F. Y. Bouget (2009). “Clocks in the Green Lineage: Comparative Functional Analysis of the Circadian Architecture of the Picoeukaryote Ostreococcus.” Plant Cell 21(11): 3436-3449.
• March 2013. Co-awardee of the Prix GREMI delivered by the GREMI, Paris, France (Groupe Français d’Etude des Médiateurs Inflammatoires/ French Group of Study of Inflammatory Mediators) of the best PhD thesis in the field of Inflammation
• March 2013. Awardee of the Prix Claude Rozé delivered by the CECED, Montpellier, France (Club of Study of Digestive Epithelial Cells)
• December 2013. Awardee of the Prix Caujolle for a PhD thesis in the field of Pharmaceutical Sciences delivered by the “Academie des Sciences, Inscriptions and Belles Lettres de Toulouse”, Toulouse, France
• March 2015. Ed McCauley Postdoctoral award, in recognition of achievements as a postdoctoral fellow at the University of Calgary.
B. Post-doctoral fellowships
• May 2013-may 2015. Canadian Institute of Health Research (CIHR)/ Canadian Association of Gastroenterology (CAG)/ Crohn’s and Colitis Foundation of Canada (CCFC) Post-Doctoral fellowship, May to September, 2013. Withdrawn in September, 1st, 2013
• May 2013- May 2015. University of Calgary Eye’s High Post-Doctoral Fellowship
• September 2013 – September 2015. Unique recipient of the 2013 Izaak Walton Killam Post-Doctoral Fellowship at the University of Calgary
• September 2015 – September 2018. Alberta Health – Innovates Health Solutions Postdoctoral Fellowship
• Joint-inventor: Pending Patent US61/827074 “Treatment of gluten-associated disorders”, 2014 . Inventors (% of participation to the invention) : E. Verdu (24%), P. Langella (23%), N. Vergnolle (23%), JP. Motta (10%), L. Bermudez-Humaran (10%), H. Galipeau (5%) J. Jury (4%), M. Wiepjes (1%)
• Technical participation aknowledgment without inventorship : 2011 WO 2011086172 A1 – Recombinant probiotic bacteria for the prevention and treatment of inflammatory bowel disease (ibd) and irritable bowel syndrome (IBS) – N.Vergnolle, JM. Sallenave, P. Langella, L. Bermudez-Humaran
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