AgreenSkills session, year: 2nd session, 2014
Receiving laboratory: PARASITE GENOMICS TEAM, WELLCOME TRUST SANGER INSTITUTE, United Kingdom
Country of origin : France
Genomic architecture of anthelminthic resistance in Haemonchus contortus
We propose to dissect the genetics of anthelminthic resistance in Haemonchus contortus, a sheep parasitic nematode, exploiting high-throuput sequencing technology. The first goal is to to mine the levamisole resistance trait in H.contortus in a selected introgression line. The second goal will be to sequence isolates from populations in regions known to be under high and low levels of anthelminthic selection pressure.
Results obtained from the two approaches will allow us to understand to what extent anthelminthic use has shaped the genetic structure of H.contortus populations and will provide new insights into the diversity and evolution of H.contortus.
|As a research engineer at INRA, I am involved in two research strands in the “war against worms”, i.e. the development of integrated strategies for field application in horses and small ruminants, and the mining of parasitic nematodes genomes to unravel novel targets. Over the first two years, I have been mostly involved with the first strand of research for which I have developed a collaborative network for both sheep and horse topics with prolific outputs (papers and granted projects). For the next years, I would like to establish myself as a veterinary parasite genomicist to mine fundamental questions associated with the management of parasitic nematodes, i.e. the genomic architecture of drug resistance and host adaptation traits.|
Léopold Escande prize for PhD work, Toulouse University (2013)
Website(s): researchgate.net/profile/Guillaume_Salle | http://www6.val-de-loire.inra.fr/infectiologie-santepublique | https://www.sanger.ac.uk/research/projects/parasitegenomics | https://www.brc4env.fr/BRCs-and-collections/Invertebrates/Nematodes