Guillaume Sallé

Guillaume Sallé
country
country

AgreenSkills session, year: 2nd session, 2014

Receiving laboratory: PARASITE GENOMICS TEAM, WELLCOME TRUST SANGER INSTITUTE, United Kingdom

Country of origin : France

E-Mail: Guillaume.Salle@tours.inra.fr

 

 

Mobility project

Genomic architecture of anthelminthic resistance in Haemonchus contortus

We propose to dissect the genetics of anthelminthic resistance in Haemonchus contortus, a sheep parasitic nematode, exploiting high-throuput sequencing technology. The first goal is to to mine the levamisole resistance trait in H.contortus in a selected introgression line. The second goal will be to sequence isolates from populations in regions known to be under high and low levels of anthelminthic selection pressure.

Results obtained from the two approaches will allow us to understand to what extent anthelminthic use has shaped the genetic structure of H.contortus populations and will provide new insights into the diversity and evolution of H.contortus.

Biography & research interests
As a research engineer at INRA, I am involved in two research strands in the “war against worms”, i.e. the development of integrated strategies for field application in horses and small ruminants, and the mining of parasitic nematodes genomes to unravel novel targets. Over the first two years, I have been mostly involved with the first strand of research for which I have developed a collaborative network for both sheep and horse topics with prolific outputs (papers and granted projects). For the next years, I would like to establish myself as a veterinary parasite genomicist to mine fundamental questions associated with the management of parasitic nematodes, i.e. the genomic architecture of drug resistance and host adaptation traits.
Selected publications
  •  Sallé G., Laing R., Cotton J.A., Holroyd N., Doyle S., Newlands G.F.J., Smith W.D., Britton C., Devaney E., 2016. Genomic and transcriptomic changes in populations of parasitic nematode Haemonchus contortus following vaccine exposure. Jacques Monod Conference, Roscoff.
  • Kornaś S, Sallé G., Skalska M, David I, Ricard A, CabaretJ. 2015. Estimation of genetic parameters for resistance to gastro-intestinal nematodes in pure blood Arabian horses. Int J Parasitol. 45(4):237-242. doi: 10.1016/j. ijpara.2014.11.003.
  • Sallé G., Moreno C.R., Boitard, S., Ruesche, J., Tircazes- Sécula, A., Bouvier, F., Aletru, M., Weisbecker, J-L, Prévot, F., Bergeaud, J-P, Trumel, C., Grisez, C., Liénard, E., Jacquiet, P., 2014. Functional investigation of a QTL affecting resistance to Haemonchus contortus in sheep. Vet Res, 17: 45:68. doi: 10.1186/1297-9716-45-68.
  • Assenza F, Elsen JM, Legarra A, Carré C, Sallé G, Robert-Granié C, Moreno CR., 2014. Genetic parameters for growth and faecal worm egg count following Haemonchus contortus experimental infestations using pedigree and molecular information. Genet Sel Evol.14(46):13. doi: 10.1186/1297-9686-46-13.

 

Awards & patents

Léopold Escande prize for PhD work, Toulouse University (2013)

Contact:

E-Mail: Guillaume.Salle@tours.inra.fr

Website(s): researchgate.net/profile/Guillaume_Salle | http://www6.val-de-loire.inra.fr/infectiologie-santepublique | https://www.sanger.ac.uk/research/projects/parasitegenomics | https://www.brc4env.fr/BRCs-and-collections/Invertebrates/Nematodes

CV: Download curriculum vitae