Grégory Bouchaud

Grégory Bouchaud
country

AgreenSkills session, year: 2nd session, 2013

Receiving laboratory: BIA Biopolymers - Interactions and Assemblies Research Unit Angers-Nantes, France

Country of origin : France

E-Mail: gregory.bouchaud@nantes.inra.fr

 

 

Mobility project

Impact of Gluten properties on the Immune system and the development of Food Allergies

Allergies are increasing continuously over the last 20 years and become a major public health problem. The food industry could introduce new artificial or transformed food proteins into human diet. Gliadin is one of the main components of the gluten fraction of the wheat. Gliadin is involved in induction of intolerance to gluten and food allergies and can be impacted by industrial food processes. The aims of this project are i) To elucidate the effects of food processing on wheat gliadins and ii) To understand the mechanism of gliadin-induced allergic reactions.

Biography & research interests

I’m a post-doctoral fellow at the Biopolymers-Assemblies-Interactions Unit (BIA) of the French National Institute for Agricultural Research (INRA). I obtained my master degree in Biophysics by studying structure, function and engineering of proteins at Paris VI University. Subsequently, I was awarded of my PhD in immunology at the University of Nantes, where I developed a strong background in immunology and cell biology. During my PhD, I elucidated the mechanisms regulating the interaction between IL-15 and its soluble receptor, IL-15Rα, thus explaining also the strong affinity between the two partners (Bouchaud G, et al., 2008 J. Mol. Biol). Moreover, I unraveled the involvement of IL-15 in cancer (Bouchaud* G, et al., 2008 Cancer Res.) and in inflammatory bowel diseases (Bouchaud G, et al., 2010 Gastroenterology). After my Ph.D, I successfully applied for a fellowship from the “foundation pour le recherché médicale” (FRM), which allowed me to perform three years of post-doctoral research in the laboratory of Professor Onur Boyman at the University Hospital of Zurich, Switzerland. In the laboratory of Prof. Boyman, my research was focused on the effect of improved formulations of IL-2 and IL-15 cytokines on different types of cancer such as melanoma and colorectal cancer and on autoimmune diseases such as lupus, psoriasis and colitis. Now, my plan is to establish new field and new techniques to develop immunology of food allergy at INRA.

Selected publications
[1] Grégory Bouchaud, Samuel Gehrke, Carsten Krieg, Jürg Hafner, Alexander A. Navirini, Lars E. French and Onur Boyman. Epidermal IL-15Ra acts as endogenous antagonist of psoriasifrom inflammation in mouse and man. J. Exp. Med. (2013) Sep 23;210(10):2105-17.Impact Factor (IF) = 13.8

[2] Maria Lolyeva, David Aebischer, Tatiana Ecoiffier, Simone Häner, Grégory Bouchaud, Carsten Krieg, Lucas Onder, Burkhard Ludewig, Laura Santambrogio, Onur Boyman, Lu Chen, Daniela Finke and Cornelia Halin. Interleukin-7 is produced by afferent lymphatic vessels and supports lymphatic drainage. Blood. (2013) Sep 26;122(13):2271-81 IF = 9.8

[3] Wolfgang Jungraithmayr, Laura Codarri, Grégory Bouchaud, Carsten Krieg, Onur Boyman Gabor Gyülvészi, Burkhard Becher, Walter Weder and Christian Münz. Cytokine complex expanded natural killer cells improve allogeneic lung transplant function via depletion of donor dendritic cells. American Journal of Respiratory and Critical Care Medecine AJRCCM. (2013) Jun 15;187(12):1349-59. IF = 11

[4] Harmonie Perdreau, Erwan Mortier, Grégory Bouchaud, Véronique Solé, Yvan Boublik, Ariane Plet, and Yannick Jacques. Different dynamics of IL-15R activation following IL-15 cis- or trans-presentation. Eur. Cyto. Net. (2010) Jun;138(7):2378-87. IF = 1.9

[5] Gregory Bouchaud, Erwan Mortier, Mathurin Flamant, Isabelle Barbieux, Ariane Plet, Jean Paul Galmiche, Yannick Jacques and Arnaud Bourreille. Interleukin-15 and its soluble receptor sIL-15R are implicated in the response to infliximab in Crohn’s disease. Gastroentero. (2010) Jun;138(7):2378-87. IF = 13

[6] Bessard A, Solé V, Bouchaud G, Quéméner A, Jacques Y. High antitumor activity of RLI, an interleukin-15 (IL-15)-IL-15 receptor {alpha} fusion protein, in metastatic melanoma and colorectal cancer. Mol.Cancer.Ther. (2009) Sep;8(9):2736-45 IF = 4.9

[7] Grégory Bouchaud, Laure Garrigue-Antar, Véronique Solé, Agnès Quéméner, Yvan Boublik, Erwan Mortier, Harmonie Perdreau, Yannick Jacques and Ariane Plet. Exon 3-encoded domain of sIL-15R contributes to high-affinity binding and is crucial for IL-15 antagonistic effect of soluble IL-15R. J. Mol. Biol. (2008) September 26;382(1):1-12 IF = 4.3

[8] Cecile Badoual*, Gregory Bouchaud*, Nour El Agueznay, Erwan Mortier, Stephane Hans, Alain Gey, Fahima Fernani, Severine Peyrard, Pierre Laurent Puig, Patrick Bruneval, Xavier Sastre, Ariane Plet, Laure Garrigue-Antar, Françoise Quintin-Colonna, Wolf H Fridman, Daniel Brasnu, Yannick Jacques, Eric Tartour. Release of the soluble alpha chain of IL-15 receptor: a new tumor evasion mechanism associated with poor clinical outcome in head and neck cancer patients. Canc. Res. (2008) May 15;68(10):3907-14. * Equal contribution as first author. IF = 7.5

Awards & patents

The soluble alpha chain of IL-15 receptor as a biomarker of survival of patients suffering from type of cancers known to express IL-15R alpha. (Inserm Tranfert). EP 08 300 131.3 3.

A method for predicting the responsiveness to an anti-TNF alpha antibody treatment. (Inserm transfert, CHU de Nantes) PCT/FR2009/050391.

Contact:

E-Mail: gregory.bouchaud@nantes.inra.fr

Website(s): http://www.cepia.inra.fr

CV: