Elena Terenina

Elena Terenina

AgreenSkills session, year: 1st session, 2014

Receiving laboratory: Department of Genetics, Genomics, and Informatics, University of Tennessee Health Science Center, Memphis, TN, USA

Country of origin : France

E-Mail: elena.terenina@toulouse.inra.fr



Mobility project

Systems genetics of stress responses

The research project that I develop at INRA aims to explore the molecular genetic mechanisms of adaptability of farm animals. My sabbatical at Memphis offers the possibility to study the same scientific issues in a model species, the mouse, with an advanced knowledge of its genome and the availability of numerous genetic tools, including the genetic reference populations such as the BXD panel of recombinant inbred strains. Our goal is to develop a comprehensive animal model to answer the fundamental question: what are the molecular bases for individual differences in adaptation to stress, and what are the underlying biobehavioral mechanisms?

Biography & research interests

I am a full-time scientist at the French National Institute for Agricultural Research (CR1 INRA), with a wide experience in molecular analysis of genetic variability of stress responses. After completing a Master of Science at the Moscow State University, I studied behavioral and neuroendocrine mechanisms involved in the process of adaptation during my PhD and post-doctoral fellowship at Bordeaux University and INRA. My research project, the molecular analysis of the genetic variability of stress responses is a critical topic to improve robustness and welfare of farm animals. Since my recruitment as a scientist at INRA (in the laboratory for PsychoNeuroImmunology, Nutrition and Genetics at INRA Bordeaux, then in the Laboratory of Livestock Genetics, Physiology and Breeding at INRA Toulouse), I have studied in more detail the genetic variability of behavioural and biological responses, especially of the hypothalamic–pituitary–adrenal axis, and its functional consequences on robustness and production traits. These three components (behavior, biology, production) are studied in the pig with an integrative approach. My scientific ambition is to deliver a strategy for genetic selection of more robust animals. My unique objective is to explore the genetic architecture of stress responses in an integrated way (system genetics) and the functional consequences of genetic variability, with the aim of the practical use of this knowledge in genetic selection.



Selected publications

Larzul C, Terenina E, Foury A, Billon Y, Louveau I, Merlot E, Mormede P. The cortisol response to ACTH in pigs, heritability and influence of corticosteroid-binding globulin. Animal, 2015

Larzul C, Terenina E, Foury A, Billon Y, Louveau I, Marlot E, Mormede P. Genetic variability of hypothalamic-pituitary adrenocortical axis activity in Large White pigs and divergent selection for the study of robustness. Annals of the French annual meeting of the scientific and technical actors of the swine network, 2014, 46

Terenina E, Yammine S, Gress L, Iannuccelli N, Lascor C, Lippi Y, Martin P, Billon Y, Labrune Y, SanCristobal M, Canario L, Liaubet L, Mormede P. Foetal development in relationship with piglet survival at birth. Adrenocortical axis and adrenal transcriptome study. Annals of the French annual meeting of the scientific and technical actors of the swine network, 2013, 45, 229-230

Terenina E, Babigumira BM, Le Mignon G, Bazovkina D, Rousseau S, Salin F, Bendixen C, Mormede P. Association study of molecular polymorphisms in candidate genes related to stress responses with production and meat quality traits in pigs. Domestic Animal Endocrinology, 2013, 44:81–97

Mormede P, Terenina E. Molecular genetics of the adrenocortical axis and breeding for robustness. Domestic Animal Endocrinology 2012, Aug;43(2):116-31

Kulikov AV, Osipova DV, Naumenko VS, Terenina E, Mormède P, Popova NK. A pharmacological evidence of positive association between mouse intermale aggression and brain serotonin metabolism. Behav Brain Res 2012, Jul 15;233(1):113-9

Terenina E, Bazovkina D, Rousseau S, Salin F, D’Eath, Turner S, Kulikov A, Mormede P. Gene polymorphisms associated with aggression in pigs. Annals of the French annual meeting of the scientific and technical actors of the swine network, 2012, 44, 45-46

Bonnet A, Bevilacqua C, Benne F, Bodin L, Cotinot C, Liaubet L, Sancristobal M, Sarry J, Terenina E, Martin P, Tosser-Klopp G, Mandon-Pepin B. Transcriptome profiling of sheep granulose cells and oocytes during early follicular development obtained by Laser Capture Microdissection. BMC Genomics 2011, 12:417

Terenina E, Rousseau S, Tridon C, Jones BC, Mormede P. Excessive alcohol consumption: study of a congenic line derived from the High Ethanol Preferring rats. Cahiers de l’IREB 2011, 20:311-315

Mormède P, Foury A, Barat P, Corcuff JB, Terenina E, Marissal-Arvy N, Moisan MP. Molecular genetics of hypothalamic–pituitary–adrenal axis activity and function. Annals of the New York Academy of Sciences 2011, 1220:127-136

Mormède P, Foury A, Terenina E, Knap PW. Breeding for robustness: the role of cortisol. Animal 2011, 5:651-657

Bazovkina DV, Terenina EE, Kulikov AV. Effect of selective agonist of serotonin 5-HT1A receptors on defensive behavior in mice with different predisposition to catalepsy. Bull Exp Biol Med. 2010, Dec;150(2):225-8

Vendruscolo LF, Vendruscolo JC, Terenina E, Ramos A, Takahashi RN, Mormède P. Marker-assisted dissection of genetic influences on motor and neuroendocrine sensitization to cocaine in rats. Genes Brain Behav. 2009, Apr;8(3):267-74

Awards & patents

First Award for the thesis from Institute for Scientific Research on Beverages (IREB);

First Award for the thesis from French Society of Alcohology (SFA)


E-Mail: elena.terenina@toulouse.inra.fr

Website(s): http://www.uthsc.edu