AgreenSkills session, year: 2nd session, 2013
Receiving laboratory: NutriNeuro Nutrition and integrated neurobiology Bordeaux Aquitaine, France
Country of origin : France
Omega-3 can protect against depression: role of the endocannabinoid-dependent neuronal plasticity
Major depressive disorder (depression) affects 350 million people in the world, however, efficient pharmacological treatments are lacking. Recently, there has been considerable attention on the role of nutrition, particularly the amount of Omega 3 fatty acids in the development of depression. The hosting laboratory has notably demonstrated that depression induced by Omega 3 deficient diet was associated with altered synaptic plasticity. In this project, we will use patch-clamp recordings to investigate how Omega 3 deficiency impairs synaptic plasticity. This study will help the understanding of mechanisms leading to depression and may provide new strategies to reduce its incidence.
I am a neuroscientist and I am mostly interested in the coding of neuronal information in normal and pathological conditions. I studied Biology and Neuroscience in Poitiers and Paris (France), successively. My initial field of interest is Parkinson’s disease, a neurodegenerative disorder that affects 1% of the population over 60 years of age and is characterized by tremor, rigidity of muscles and slowing of movements, as well as sleep disorders and depression. Technically, I have learned to master several techniques of electrophysiology which allow a direct recording of the electrical communication between neurons in the brain. During my PhD, I used patch-clamp electrophysiological recordings to investigate the mechanism of action of deep brain stimulation, a therapy used for Parkinson’s disease. For my first postdoctoral fellowship at the University of Otago (New Zealand), I used the cutting edge technique of optogenetic stimulation combined with electrophysiological recordings in freely moving rodents to better understand the pathophysiology of Parkinson’s disease. For my second postdoctoral fellowship in the Nutrineuro lab (INRA, Bordeaux, France), I will investigate the mechanisms by which a diet deficient in Omega 3 fatty acids produces depressive disorders, associated with strong impairments in the endocannabinoid-dependent synaptic plasticity. In the future, I wish to continue in this research area to better understand how much the food can control brain functions. I also aim to develop more and more sophisticated techniques to answer complex biological questions.
Bosch-Bouju C, Hyland BI, Parr-Brownlie LC (2013) Motor thalamus integration of cortical, cerebellar and basal ganglia information : implications for normal and parkinsonian conditions. Frontiers in Computational Neuroscience 7 :163.
Nelson MJ, Bosch C, Venance L, Pouget P (2013) Microscale inhomogeneity of brain tissue distorts electrical signal propagation. Journal of Neuroscience 33, 2821-2828.
Bosch C, Mailly P, Degos B, Deniau JM, Venance L (2012) Preservation of the hyperdirect pathway of basal ganglia in a rodent brain slice. Neuroscience 215, 31-41.
Bosch C, Degos B, Deniau JM, Venance L (2011) Subthalamic nucleus high frequency stimulation generates a concomitant synaptic excitation-inhibition in substantia nigra pars reticulata. J Physiol 589:4189-4207.
Deniau JM, Degos B, Bosch C, Maurice N (2010) Deep brain stimulation mechanisms: beyond the concept of local functional inhibition. Eur J Neurosci 32, 1080-1091.
Bertran-Gonzalez J, Bosch C, Maroteaux M, Matamales M, Herve D, Valjent E, Girault JA (2008) Opposing patterns of signaling activation in dopamine D1 and D2 receptor-expressing striatal neurons in response to cocaine and haloperidol. Journal of Neuroscience 28, 5671-5685.
First Prize for the Research Staff Speaker Awards of the Otago School of Medical Science (2013) with the oral presentation: Bosch-Bouju C, Hyland BI, Parr-Brownlie LC. Movement-related neuronal activity in the motor thalamus is strongly impaired in a Parkinson’s disease rat model.
Travel Fellowships from the Neurological Foundation of New Zealand and from the IBAGS committee for attending the IBAGS XI meeting in Eilat (Israel) in March 2013
Travel Fellowship from the French Neuroscience Society for attending the 10th French Neuroscience meeting in Marseille in May 2011